Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl4 model of acute liver failure
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Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl4 model of acute liver failure.
Acute liver failure was induced in rats by CCl4 administration and its effects on the hepatic Krebs cycle and gluconeogenic fluxes were evaluated in situ by 13C NMR isotopomer analysis of hepatic glucose following infusion of [U-13C]propionate. In fed animals, CCl4 injury caused a significant increase in relative gluconeogenic flux from 0.80+/-0.10 to 1.34 +/-0.24 times the flux through citrate...
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ژورنال
عنوان ژورنال: NMR in Biomedicine
سال: 2002
ISSN: 0952-3480,1099-1492
DOI: 10.1002/nbm.745